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Study Information
Study Attribute Value
CEBS Accession Number: 002-02563-0002-0000-0
Chemical Name: N-Nitrosomorpholine
CASRN: 59-89-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 579986_CA
Study Result: Not a Valid Test

Study Result: Not a Valid Test
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Test Failure 

Trial #:1   Activation: No Activation    Date: 08/18/1987    Harvest Time: 10.1 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 9 0.045 4.5 3 0.015 1.5 6 0.030 3.0 0 0.000 0.0
Medium 
0         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: N-Nitrosomorpholine 
2500         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
3750         
 200 6 0.030 3.0 1 0.005 0.5 5 0.025 2.5 0 0.000 0.0 
5000         
 200 11 0.055 4.5 4 0.020 2.0 7 0.035 2.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 200 29 0.145 12.5 6 0.030 3.0 23 0.115 10.0 0 0.000 0.0
Mitomycin-C 
 0.75      
 25 15 0.600 28.0 4 0.160 16.0 11 0.440 20.0 0 0.000 0.0
Trend: 2.022 0.883 1.874  
Probability: 0.022 0.189 0.030  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/18/1987    Harvest Time: 12 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0
Medium 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: N-Nitrosomorpholine 
2500         
 200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0 
3750         
 200 10 0.050 4.5 5 0.025 2.0 5 0.025 2.5 0 0.000 0.0 
5000         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 16 0.080 7.5 8 0.040 4.0 8 0.040 3.5 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 17 0.680 40.0 5 0.200 16.0 12 0.480 32.0 0 0.000 0.0
Trend: 1.297 1.562 0.502  
Probability: 0.097 0.059 0.308