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Study Information
Study Attribute Value
CEBS Accession Number: 002-02563-0005-0000-3
Chemical Name: N-Nitrosomorpholine
CASRN: 59-89-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 958084_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/22/83 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Test Chemical N-Nitrosomorpholine 
375         
 8 14.25 ± 3.88 0.0000
  
750         
 8 38.25 ± 4.51 0.0000
  
1500         
 8 41.25 ± 4.69 0.0000
Vehicle Control No Stressor 
 0         
 8 0.25 ± 0.25 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/13/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0251
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 13.00 ± 2.04 0.0000
Test Chemical N-Nitrosomorpholine 
50         
 7 1.43 ± 0.37 0.5324
  
100         
 8 0.75 ± 0.37 0.8427
  
200         
 8 3.25 ± 1.31 0.0520
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.82 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed