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Study Information
Study Attribute Value
CEBS Accession Number: 002-02565-0001-0000-1
Chemical Name: N-Phenyl-1-naphthylamine
CASRN: 90-30-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 997330_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/28/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 375 0.359 7.50 26.5 0.000
Test Chemical N-Phenyl-1-naphthylamine 
1.82      
 50 1034 391 0.378 7.82 26.5 5.477 
6.05      
 50 1030 396 0.384 7.92 26.5 7.240 
18.2       
 50 1039 426 0.410 8.52 26.5 14.365 
60.5       
 0 0 0 0.000 0.00 30.5 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1033 493 0.477 9.86 26.5 33.121
Mitomycin-C 
 0.01      
 11 230 219 0.952 19.91 26.5 165.593
Trend: 1.870        
Probability: 0.031        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/28/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 400 0.381 8.00 26.0 0.000
Test Chemical N-Phenyl-1-naphthylamine 
 0.605     
 50 1048 449 0.428 8.98 26.0 12.357 
6.05      
 50 1044 443 0.424 8.86 26.0 11.280 
18.2       
 50 1046 500 0.478 10.00 26.0 25.359 
60.5       
 0 0 0 0.000 0.00 30.0 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1037 515 0.497 10.30 26.0 30.240
Cyclophosphamide 
2.5       
 10 210 293 1.395 29.30 26.0 265.901
Trend: 2.992        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/18/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 420 0.407 8.40 26.0 0.000
Test Chemical N-Phenyl-1-naphthylamine 
9.95      
 50 1041 504 0.484 10.08 26.0 18.847 
15         
 50 1048 556 0.531 11.12 26.0 30.234 
19.9       
 50 1048 603 0.575 12.06 26.0 41.243 
24.9       
 0 0 0 0.000 0.00 30.0 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1047 512 0.489 10.24 26.0 20.042
Cyclophosphamide 
2.5       
 10 211 199 0.943 19.90 26.0 131.515
Trend: 5.588        
Probability: 0.000