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Study Information
Study Attribute Value
CEBS Accession Number: 002-02565-0002-0000-2
Chemical Name: N-Phenyl-1-naphthylamine
CASRN: 90-30-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 997330_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 03/13/1986    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 7 0.035 3.0 1 0.005 1.0 6 0.030 3.0 0 0.000 0.0
Test Chemical: N-Phenyl-1-naphthylamine 
2.99      
 200 13 0.065 6.0 2 0.010 1.0 11 0.055 5.0 0 0.000 0.0 
9.95      
 200 10 0.050 3.0 0 0.000 0.0 9 0.045 3.0 1 0.005 1.0 
29.9       
 200 19 0.095 5.0 2 0.010 1.0 7 0.035 4.0 10 0.050 1.0 
49.8       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 50 52 1.040 44.0 8 0.160 16.0 24 0.480 28.0 20 0.400 2.0
Mitomycin-C 
5         
 50 64 1.280 56.0 17 0.340 30.0 27 0.540 32.0 20 0.400 2.0
Trend: 0.400 -0.376 0.115  
Probability: 0.344 0.646 0.454  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/06/1986    Harvest Time: 12 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 10 0.050 3.0 2 0.010 1.0 8 0.040 3.0 0 0.000 0.0
Test Chemical: N-Phenyl-1-naphthylamine 
1.49      
 200 17 0.085 6.5 3 0.015 2.0 13 0.065 5.0 1 0.005 1.0 
4.95      
 200 11 0.055 4.5 2 0.010 1.0 7 0.035 3.0 2 0.010 2.0 
14.9       
 200 18 0.090 7.5 4 0.020 2.0 14 0.070 6.0 0 0.000 0.0 
29.7       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 74 1.480 62.0 25 0.500 34.0 28 0.560 34.0 21 0.420 3.0
Trend: 1.568 0.492 1.066  
Probability: 0.058 0.311 0.143  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 03/20/1986    Harvest Time: 20 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 2.0 0 0.000 0.0
Test Chemical: N-Phenyl-1-naphthylamine 
9.95      
 200 13 0.065 5.0 4 0.020 2.0 9 0.045 4.0 0 0.000 0.0 
14.9       
 200 9 0.045 3.5 1 0.005 1.0 8 0.040 4.0 0 0.000 0.0 
19.9       
 200 13 0.065 4.0 4 0.020 2.0 8 0.040 2.0 1 0.005 1.0 
29.8       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 10 74 7.400 90.0 2 0.200 20.0 2 0.200 20.0 70 7.000 7.0
Trend: 1.034 1.390 0.079  
Probability: 0.151 0.082 0.469