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Study Information
Study Attribute Value
CEBS Accession Number: 002-02566-0001-0000-2
Chemical Name: N-Phenyl-2-naphthylamine
CASRN: 135-88-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 796411_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 02/04/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1021 356 0.349 7.12 26.5 0.000
Test Chemical N-Phenyl-2-naphthylamine 
1.14      
 50 1041 402 0.386 8.04 26.5 10.752 
3.41      
 50 1036 348 0.336 6.96 26.5 -3.663 
11.4       
 50 1041 378 0.363 7.56 26.5 4.140 
34.1       
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1033 510 0.494 10.20 26.5 41.594
Mitomycin-C 
 0.01      
 10 209 201 0.962 20.10 26.5 175.820
Trend: -0.068        
Probability: 0.527        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/04/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 435 0.417 8.70 26.0 0.000
Test Chemical N-Phenyl-2-naphthylamine 
3.41      
 50 1046 503 0.481 10.06 26.0 15.411 
11.4       
 50 1046 522 0.499 10.44 26.0 19.771 
34.1       
 50 1042 530 0.509 10.60 30.0 22.073 
114         
 0 0 0 0.000 0.00 30.0 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1046 531 0.508 10.62 26.0 21.836
Cyclophosphamide 
2.5       
 10 211 239 1.133 23.90 26.0 171.848
Trend: 3.091        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/11/1986    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1038 476 0.459 9.52 26.0 -7.573
Dimethyl Sulfoxide 
0         
 50 1038 515 0.496 10.30 26.0 0.000
Test Chemical N-Phenyl-2-naphthylamine 
5         
 50 1042 611 0.586 12.22 26.0 18.185 
10         
 50 1045 588 0.563 11.76 26.0 13.410 
20         
 50 1042 519 0.498 10.38 26.0 0.390 
30         
 50 1047 585 0.559 11.70 30.0 12.616 
40         
 10 208 161 0.774 16.10 30.0 56.010
Positive Control Cyclophosphamide 
 0.5       
 50 1043 692 0.663 13.84 26.0 33.725
Cyclophosphamide 
2.5       
 10 208 261 1.255 26.10 26.0 152.911
Trend: 1.643        
Probability: 0.050