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Study Information
Study Attribute Value
CEBS Accession Number: 002-02566-0002-0000-3
Chemical Name: N-Phenyl-2-naphthylamine
CASRN: 135-88-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 796411_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 02/13/1986    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 7 0.035 3.0 4 0.020 2.0 3 0.015 1.0 0 0.000 0.0
Test Chemical: N-Phenyl-2-naphthylamine 
2.97      
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
9.9       
 200 4 0.020 2.0 1 0.005 1.0 3 0.015 2.0 0 0.000 0.0 
29.7       
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
49.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 31 0.155 14.0 11 0.055 6.0 20 0.100 8.0 0 0.000 0.0
Mitomycin-C 
5         
 50 18 0.360 22.0 10 0.200 14.0 8 0.160 14.0 0 0.000 0.0
Trend: -1.146 -1.741 0.292  
Probability: 0.874 0.959 0.385  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/13/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 12 0.060 6.0 2 0.010 1.0 10 0.050 5.0 0 0.000 0.0
Test Chemical: N-Phenyl-2-naphthylamine 
2.97      
 200 12 0.060 6.0 1 0.005 1.0 11 0.055 5.0 0 0.000 0.0 
9.9       
 200 6 0.030 3.0 1 0.005 1.0 5 0.025 2.0 0 0.000 0.0 
29.7       
 200 36 0.180 8.0 1 0.005 1.0 15 0.075 7.0 20 0.100 2.0 
49.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 21 0.420 28.0 9 0.180 18.0 12 0.240 14.0 0 0.000 0.0
Trend: 0.406 0.000 0.445  
Probability: 0.342 0.500 0.328