Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02567-0001-0000-3 |
Chemical Name: | N-Phenyl-p-phenylenediamine |
CASRN: | 101-54-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 887002_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Weakly Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1049 | 511 | 0.487 | 10.22 | 26.5 | 0.000 |
Test Chemical | N-Phenyl-p-phenylenediamine | 0.16 | 50 | 1049 | 489 | 0.466 | 9.78 | 26.5 | -4.305 |
0.5 | 50 | 1050 | 515 | 0.490 | 10.30 | 26.5 | 0.687 | ||
1.6 | 50 | 1050 | 713 | 0.679 | 14.26 | 26.5 | 39.397 | ||
5 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1050 | 698 | 0.665 | 13.96 | 26.5 | 36.465 |
Mitomycin-C | 0.005 | 10 | 208 | 309 | 1.486 | 30.90 | 26.5 | 204.965 | |
Trend: | 5.985 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1051 | 469 | 0.446 | 9.38 | 27.0 | 0.000 |
Test Chemical | N-Phenyl-p-phenylenediamine | 0.5 | 50 | 1047 | 461 | 0.440 | 9.22 | 27.0 | -1.330 |
1 | 50 | 1046 | 489 | 0.467 | 9.78 | 27.0 | 4.763 | ||
2 | 50 | 1051 | 617 | 0.587 | 12.34 | 31.5 | 31.557 | ||
3 | 50 | 1049 | 756 | 0.721 | 15.12 | 31.5 | 61.501 | ||
4 | 0 | 0 | 0 | 0.000 | 0.00 | 31.5 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1049 | 666 | 0.635 | 13.32 | 27.0 | 42.275 |
Mitomycin-C | 0.005 | 10 | 210 | 339 | 1.614 | 33.90 | 27.0 | 261.751 | |
Trend: | 9.615 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1050 | 394 | 0.375 | 7.88 | 26.0 | 0.000 |
Test Chemical | N-Phenyl-p-phenylenediamine | 5 | 50 | 1050 | 465 | 0.443 | 9.30 | 26.0 | 18.020 |
16 | 50 | 1048 | 417 | 0.398 | 8.34 | 26.0 | 6.040 | ||
50 | 50 | 1049 | 503 | 0.480 | 10.06 | 26.0 | 27.787 | ||
160 | 50 | 1046 | 530 | 0.507 | 10.60 | 26.0 | 35.032 | ||
500 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.3 | 50 | 1051 | 689 | 0.656 | 13.78 | 26.0 | 74.707 |
Cyclophosphamide | 0.6 | 10 | 210 | 179 | 0.852 | 17.90 | 26.0 | 127.157 | |
Trend: | 4.615 | ||||||||
Probability: | 0.000 |