Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02567-0002-0000-4 |
Chemical Name: | N-Phenyl-p-phenylenediamine |
CASRN: | 101-54-2 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 887002_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Questionable |
Induced Rat Liver S9 | 1_S9 | Positive |
No Activation | 2 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | N-Phenyl-p-phenylenediamine | 0.5 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
1 | 100 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
2.5 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
5 | 100 | 10 | 0.100 | 8.0 | 2 | 0.020 | 1.0 | 8 | 0.080 | 7.0 | 0 | 0.000 | 0.0 | ||
10 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.15 | 100 | 31 | 0.310 | 16.0 | 6 | 0.060 | 4.0 | 15 | 0.150 | 12.0 | 10 | 0.100 | 1.0 |
Trend: | 1.986 | 0.493 | 1.925 | ||||||||||||
Probability: | 0.024 | 0.311 | 0.027 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | N-Phenyl-p-phenylenediamine | 10 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
25 | 100 | 36 | 0.360 | 15.0 | 24 | 0.240 | 14.0 | 12 | 0.120 | 5.0 | 0 | 0.000 | 0.0 | ||
50 | 100 | 27 | 0.270 | 15.0 | 18 | 0.180 | 12.0 | 9 | 0.090 | 7.0 | 0 | 0.000 | 0.0 | ||
75 | 100 | 29 | 0.290 | 18.0 | 19 | 0.190 | 11.0 | 10 | 0.100 | 10.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 100 | 45 | 0.450 | 33.0 | 26 | 0.260 | 22.0 | 18 | 0.180 | 15.0 | 1 | 0.010 | 1.0 |
Trend: | 5.378 | 4.410 | 3.762 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | N-Phenyl-p-phenylenediamine | 2.5 | 100 | 15 | 0.150 | 9.0 | 7 | 0.070 | 5.0 | 8 | 0.080 | 6.0 | 0 | 0.000 | 0.0 |
5 | 100 | 45 | 0.450 | 10.0 | 19 | 0.190 | 8.0 | 5 | 0.050 | 4.0 | 21 | 0.210 | 3.0 | ||
7.5 | 100 | 34 | 0.340 | 17.0 | 16 | 0.160 | 12.0 | 8 | 0.080 | 7.0 | 10 | 0.100 | 1.0 | ||
10 | 100 | 111 | 1.110 | 36.0 | 58 | 0.580 | 28.0 | 13 | 0.130 | 9.0 | 40 | 0.400 | 4.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 100 | 22 | 0.220 | 17.0 | 12 | 0.120 | 11.0 | 10 | 0.100 | 8.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 52 | 1.040 | 54.0 | 33 | 0.660 | 38.0 | 19 | 0.380 | 26.0 | 0 | 0.000 | 0.0 | |
Trend: | 6.768 | 6.097 | 2.592 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.005 |