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Study Information
Study Attribute Value
CEBS Accession Number: 002-02574-0001-0000-1
Chemical Name: m-Nitrotoluene
CASRN: 99-08-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 713359_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/10/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 434 0.421 8.68 25.5 0.000
Test Chemical m-Nitrotoluene 
3.84      
 50 1020 488 0.478 9.76 25.5 13.655 
11.5       
 50 1029 442 0.430 8.84 25.5 2.041 
38.4       
 50 986 475 0.482 9.50 25.5 14.442 
115         
 28 556 297 0.534 10.61 25.5 26.897
Positive Control Mitomycin-C 
 0.005     
 25 511 851 1.665 34.04 25.5 295.619
Trend: 2.751        
Probability: 0.003        

Trial #: 2    Activation: No Activation    Date: 01/28/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 477 0.456 9.54 25.5 0.000
Test Chemical m-Nitrotoluene 
150         
 50 1035 616 0.595 12.32 33.3 30.388 
196         
 50 1033 576 0.558 11.52 33.3 22.157 
253         
 50 1017 585 0.575 11.70 33.3 26.018
Positive Control Mitomycin-C 
 0.005     
 25 519 866 1.669 34.64 25.5 265.551
Trend: 3.117        
Probability: 0.001        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/14/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1003 343 0.342 6.86 25.5 0.000
Test Chemical m-Nitrotoluene 
38.4       
 50 1021 307 0.301 6.14 25.5 -12.074 
115         
 50 1009 356 0.353 7.12 25.5 3.173 
384         
 50 989 313 0.316 6.26 25.5 -7.455
Positive Control Cyclophosphamide 
1.5       
 25 505 522 1.034 20.88 25.5 202.264
Trend: -0.319        
Probability: 0.625