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Study Information
Study Attribute Value
CEBS Accession Number: 002-02575-0002-0000-3
Chemical Name: o-Nitrotoluene
CASRN: 88-72-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 573604_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9   

Trial #:1   Activation: No Activation    Date: 10/22/1981    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 2 0.020 2.0 1 0.010 1.0
Test Chemical: o-Nitrotoluene 
200.7       
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
252.5       
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
393.6       
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 100 20 0.200 16.0 13 0.130 12.0 7 0.070 6.0 0 0.000 0.0
Trend: -1.140 0.755 -1.733  
Probability: 0.873 0.225 0.958  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/11/1981    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 1.0 0 0.000 0.0 2 0.020 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 4.0 0 0.000 0.0 2 0.020 2.0 3 0.030 3.0
Test Chemical: o-Nitrotoluene 
375.36      
 100 3 0.030 2.0 1 0.010 1.0 2 0.020 1.0 0 0.000 0.0 
398.82      
 100 9 0.090 8.0 1 0.010 1.0 8 0.080 7.0 0 0.000 0.0 
422.28      
 100 5 0.050 5.0 2 0.020 2.0 2 0.020 2.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
50         
 100 30 0.300 20.0 20 0.200 14.0 10 0.100 8.0 0 0.000 0.0
Trend: 0.963 1.344 0.815  
Probability: 0.168 0.089 0.208  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 10/22/1981    Harvest Time: 10.5 hour(s)   Trial Call:   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 6 0.060 4.0 2 0.020 2.0 4 0.040 2.0 0 0.000 0.0
Test Chemical: o-Nitrotoluene 
393.6       
 100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
25         
 100 29 0.290 19.0 18 0.180 14.0 11 0.110 9.0 0 0.000 0.0
Trend: 0.000 0.000 0.000  
Probability: 0.000 0.000 0.000