COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02579-0002-0000-7
Chemical Name: Naphthalene
CASRN: 91-20-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 040612_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 11/16/1987    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Naphthalene 
37.5       
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
75         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
112.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 31 0.155 11.0 22 0.110 9.0 9 0.045 4.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 25 1.000 48.0 13 0.520 32.0 12 0.480 32.0 0 0.000 0.0
Trend: 1.003 0.832 0.637  
Probability: 0.158 0.203 0.262  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/16/1987    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 7 0.035 3.5 0 0.000 0.0 7 0.035 3.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Naphthalene 
30         
 200 29 0.145 11.0 9 0.045 4.0 20 0.100 7.0 0 0.000 0.0 
45         
 100 27 0.270 20.0 10 0.100 10.0 17 0.170 14.0 0 0.000 0.0 
67.5       
 100 50 0.500 32.0 18 0.180 14.0 32 0.320 22.0 0 0.000 0.0 
90         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 31 0.155 13.5 14 0.070 6.5 17 0.085 7.5 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 17 0.680 44.0 5 0.200 20.0 12 0.480 28.0 0 0.000 0.0
Trend: 7.801 5.034 6.658  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 11/16/1987    Harvest Time: 10.2 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Naphthalene 
15         
 200 2 0.010 0.5 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
37.5       
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 200 19 0.095 8.5 6 0.030 3.0 13 0.065 6.0 0 0.000 0.0
Mitomycin-C 
 0.75      
 25 6 0.240 24.0 4 0.160 16.0 2 0.080 8.0 0 0.000 0.0
Trend: -1.002 -0.708 -1.002  
Probability: 0.842 0.760 0.842  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 11/23/1987    Harvest Time: 20.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Naphthalene 
45         
 200 29 0.145 8.5 10 0.050 4.5 19 0.095 5.5 0 0.000 0.0 
56.25      
 200 39 0.195 13.5 8 0.040 4.0 31 0.155 10.5 0 0.000 0.0 
67.5       
 200 37 0.185 16.0 16 0.080 7.0 21 0.105 10.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 23 0.115 11.5 8 0.040 4.0 15 0.075 7.5 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 19 0.760 52.0 6 0.240 20.0 13 0.520 40.0 0 0.000 0.0
Trend: 5.741 3.327 4.544  
Probability: 0.000 0.000 0.000