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Study Information
Study Attribute Value
CEBS Accession Number: 002-02587-0001-0000-5
Chemical Name: Nickelocene
CASRN: 1271-28-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 474085_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/03/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 463 0.446 9.26 25.5 0.000
Test Chemical Nickelocene 
25         
 50 1042 449 0.431 8.98 25.5 -3.396 
83         
 50 1029 477 0.464 9.54 25.5 3.925 
250         
 50 1041 517 0.497 10.34 25.5 11.341
Positive Control Mitomycin-C 
 0.001     
 50 1045 596 0.570 11.92 25.5 27.863
Mitomycin-C 
 0.01      
 5 104 206 1.981 41.20 25.5 344.069
Trend: 1.959        
Probability: 0.025        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/03/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 484 0.462 9.68 25.5 0.000
Test Chemical Nickelocene 
25         
 50 1044 424 0.406 8.48 25.5 -12.061 
83         
 50 1042 505 0.485 10.10 25.5 4.940 
250         
 50 1043 484 0.464 9.68 25.5 0.479
Positive Control Cyclophosphamide 
 0.34      
 50 1046 696 0.665 13.92 25.5 44.077
Cyclophosphamide 
2         
 5 103 176 1.709 35.20 25.5 269.991
Trend: 0.934        
Probability: 0.175