Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02587-0002-0000-6 |
Chemical Name: | Nickelocene |
CASRN: | 1271-28-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 474085_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 30 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 4.0 | |
Test Chemical: | Nickelocene | 153 | 100 | 10 | 0.100 | 3.0 | 1 | 0.010 | 1.0 | 9 | 0.090 | 2.0 | 0 | 0.000 | 0.0 |
204 | 100 | 4 | 0.040 | 4.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | ||
255 | 100 | 6 | 0.060 | 5.0 | 4 | 0.040 | 3.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | ||
Positive Control: | Mitomycin-C | 10 | 50 | 24 | 0.480 | 28.0 | 15 | 0.300 | 20.0 | 9 | 0.180 | 12.0 | 0 | 0.000 | 0.0 |
Trend: | 0.102 | 1.904 | -1.327 | ||||||||||||
Probability: | 0.459 | 0.028 | 0.908 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 4 | 0.040 | 4.0 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 4 | 0.040 | 4.0 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Nickelocene | 153 | 100 | 4 | 0.040 | 4.0 | 1 | 0.010 | 1.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
204 | 100 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 2 | 0.020 | 2.0 | ||
255 | 100 | 4 | 0.040 | 4.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 14 | 0.280 | 20.0 | 7 | 0.140 | 12.0 | 7 | 0.140 | 12.0 | 0 | 0.000 | 0.0 |
Trend: | 0.000 | -0.795 | -0.158 | ||||||||||||
Probability: | 0.500 | 0.787 | 0.563 |