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Study Information
Study Attribute Value
CEBS Accession Number: 002-02592-0001-0000-1
Chemical Name: Nithiazide
CASRN: 139-94-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 552942_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/08/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 442 0.423 8.84 26.0 0.000
Test Chemical Nithiazide 
 0.16      
 50 1043 471 0.452 9.42 26.0 6.868 
 0.5       
 50 1046 465 0.445 9.30 26.0 5.204 
1.6       
 50 1045 485 0.464 9.70 26.0 9.834 
5         
 50 1046 396 0.379 7.92 26.0 -10.407 
16         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1041 591 0.568 11.82 26.0 34.353
Mitomycin-C 
 0.005     
 10 210 272 1.295 27.20 26.0 206.520
Trend: -1.169        
Probability: 0.879        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/08/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 436 0.417 8.72 26.0 0.000
Test Chemical Nithiazide 
5         
 50 1038 473 0.456 9.46 26.0 9.322 
16         
 50 1046 510 0.488 10.20 26.0 16.972 
50         
 50 1046 577 0.552 11.54 26.0 32.339 
160         
 50 1041 594 0.571 11.88 26.0 36.893 
500         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.1       
 50 1044 600 0.575 12.00 26.0 37.878
Cyclophosphamide 
 0.6       
 10 211 235 1.114 23.50 26.0 167.196
Trend: 5.848        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/26/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 426 0.406 8.52 26.0 0.000
Test Chemical Nithiazide 
100         
 50 1050 522 0.497 10.44 26.0 22.535 
160         
 50 1050 544 0.518 10.88 26.0 27.700 
300         
 50 1048 560 0.534 11.20 31.0 31.706 
500         
 50 1048 547 0.522 10.94 31.0 28.649
Positive Control Cyclophosphamide 
 0.1       
 50 1046 552 0.528 11.04 26.0 30.073
Cyclophosphamide 
 0.6       
 10 210 251 1.195 25.10 26.0 194.601
Trend: 3.890        
Probability: 0.000