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Study Information
Study Attribute Value
CEBS Accession Number: 002-02592-0002-0000-2
Chemical Name: Nithiazide
CASRN: 139-94-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 552942_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 08/19/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 7 0.035 3.5 1 0.005 0.5 6 0.030 3.0 0 0.000 0.0
Test Chemical: Nithiazide 
50         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
100         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
160         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
300         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 35 0.175 16.5 19 0.095 9.0 16 0.080 8.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 17 0.340 28.0 3 0.060 6.0 14 0.280 24.0 0 0.000 0.0
Trend: -2.346 -1.363 -2.003  
Probability: 0.991 0.914 0.977  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/21/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 6 0.030 3.0 0 0.000 0.0 6 0.030 3.0 0 0.000 0.0
Test Chemical: Nithiazide 
100         
 200 9 0.045 4.5 1 0.005 0.5 8 0.040 4.0 0 0.000 0.0 
160         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
300         
 200 4 0.020 1.5 1 0.005 0.5 3 0.015 1.0 0 0.000 0.0 
500         
 200 6 0.030 2.5 0 0.000 0.0 6 0.030 2.5 0 0.000 0.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 25 0.125 12.0 6 0.030 3.0 19 0.095 9.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 12 0.240 20.0 6 0.120 10.0 6 0.120 10.0 0 0.000 0.0
Trend: -1.087 0.053 -1.146  
Probability: 0.861 0.479 0.874