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Study Information
Study Attribute Value
CEBS Accession Number: 002-02593-0001-0000-2
Chemical Name: Nitrilotriacetic acid (NTA)
CASRN: 139-13-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 267428_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/15/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1035 339 0.328 6.78 26.5 0.000
Test Chemical Nitrilotriacetic acid (NTA) 
 0.5       
 50 1037 362 0.349 7.24 26.5 6.579 
1.51      
 50 1048 361 0.344 7.22 26.5 5.169 
5.01      
 50 1050 362 0.345 7.24 26.5 5.259
Positive Control Mitomycin-C 
 0.0015    
 50 1052 638 0.606 12.76 26.5 85.159
Mitomycin-C 
 0.01      
 10 205 291 1.420 29.10 26.5 333.391
Trend: 0.578        
Probability: 0.281        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/15/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 385 0.368 7.70 26.0 0.000
Test Chemical Nitrilotriacetic acid (NTA) 
 0.5       
 50 1047 361 0.345 7.22 26.0 -6.234 
1.51      
 50 1047 370 0.353 7.40 26.0 -3.896 
5.01      
 50 1046 391 0.374 7.82 26.0 1.656
Positive Control Cyclophosphamide 
 0.5       
 50 1047 551 0.526 11.02 26.0 43.117
Cyclophosphamide 
2.5       
 10 210 265 1.262 26.50 26.0 243.173
Trend: 0.331        
Probability: 0.370