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Study Information
Study Attribute Value
CEBS Accession Number: 002-02593-0002-0000-3
Chemical Name: Nitrilotriacetic acid (NTA)
CASRN: 139-13-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 267428_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 01/28/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Nitrilotriacetic acid (NTA) 
 0.5       
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
1.5       
 100 6 0.060 4.0 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 
5         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
5         
 50 78 1.560 60.0 15 0.300 26.0 23 0.460 34.0 40 0.800 4.0
Trend: 1.254 0.410 1.453  
Probability: 0.105 0.341 0.073  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/28/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Nitrilotriacetic acid (NTA) 
 0.5       
 100 2 0.020 1.0 0 0.000 0.0 2 0.020 1.0 0 0.000 0.0 
1.5       
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
5         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 29 0.580 40.0 10 0.200 20.0 19 0.380 26.0 0 0.000 0.0
Trend: -1.071 0.015 -1.219  
Probability: 0.858 0.494 0.889