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Study Information
Study Attribute Value
CEBS Accession Number: 002-02595-0001-0000-4
Chemical Name: Nitrobenzene
CASRN: 98-95-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 694968_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/27/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 468 0.447 9.36 26.0 0.000
Test Chemical Nitrobenzene 
16         
 50 1050 372 0.354 7.44 26.0 -20.664 
50         
 50 1045 381 0.365 7.62 26.0 -18.356 
160         
 50 1050 435 0.414 8.70 26.0 -7.228
Positive Control Mitomycin-C 
 0.005     
 50 1047 863 0.824 17.26 26.0 84.578
Trend: -0.987        
Probability: 0.838        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/27/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 490 0.466 9.80 26.0 0.000
Test Chemical Nitrobenzene 
160         
 50 1050 462 0.440 9.24 26.0 -5.624 
500         
 50 1048 471 0.449 9.42 26.0 -3.602 
1600         
 50 1047 499 0.477 9.98 28.0 2.226
Positive Control Cyclophosphamide 
1         
 50 1050 805 0.767 16.10 26.0 64.442
Trend: 0.435        
Probability: 0.332