Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02595-0002-0000-5 |
Chemical Name: | Nitrobenzene |
CASRN: | 98-95-3 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 694968_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 5 | 0.050 | 5.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Nitrobenzene | 50 | 100 | 7 | 0.070 | 7.0 | 2 | 0.020 | 2.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 |
160 | 100 | 6 | 0.060 | 6.0 | 1 | 0.010 | 1.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | ||
500 | 100 | 5 | 0.050 | 5.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.15 | 50 | 32 | 0.640 | 40.0 | 10 | 0.200 | 20.0 | 22 | 0.440 | 24.0 | 0 | 0.000 | 0.0 |
Trend: | -0.095 | -0.202 | 0.001 | ||||||||||||
Probability: | 0.538 | 0.580 | 0.500 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 5 | 0.050 | 5.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Nitrobenzene | 160 | 100 | 6 | 0.060 | 6.0 | 0 | 0.000 | 0.0 | 6 | 0.060 | 6.0 | 0 | 0.000 | 0.0 |
500 | 100 | 5 | 0.050 | 5.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | ||
1600 | 100 | 8 | 0.080 | 8.0 | 2 | 0.020 | 2.0 | 6 | 0.060 | 6.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 50 | 16 | 0.320 | 28.0 | 7 | 0.140 | 14.0 | 9 | 0.180 | 18.0 | 0 | 0.000 | 0.0 |
Trend: | 0.756 | 0.900 | 0.413 | ||||||||||||
Probability: | 0.225 | 0.184 | 0.340 |