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Study Information
Study Attribute Value
CEBS Accession Number: 002-02597-0001-0000-6
Chemical Name: Nitrofen
CASRN: 1836-75-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 363245_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/31/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 413 0.394 8.26 26.0 0.000
Test Chemical Nitrofen 
 0.16      
 50 1050 447 0.426 8.94 26.0 8.129 
 0.5       
 50 1048 432 0.412 8.64 26.0 4.700 
1.6       
 50 1047 459 0.438 9.18 26.0 11.350 
5         
 50 1048 427 0.407 8.54 26.0 3.488 
16         
 11 231 84 0.364 7.64 26.0 -7.638
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 561 0.534 11.22 26.0 35.706
Mitomycin-C 
 0.005     
 10 211 254 1.204 25.40 26.0 205.757
Trend: 0.108        
Probability: 0.457        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/31/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1052 472 0.449 9.44 26.0 0.000
Test Chemical Nitrofen 
1.6       
 50 1050 451 0.430 9.02 26.0 -4.267 
5         
 50 1050 444 0.423 8.88 26.0 -5.753 
16         
 50 1050 498 0.474 9.96 26.0 5.709 
50         
 50 1049 488 0.465 9.76 26.0 3.686
Positive Control Cyclophosphamide 
 0.1       
 50 1051 615 0.585 12.30 26.0 30.421
Cyclophosphamide 
 0.6       
 10 210 209 0.995 20.90 26.0 121.820
Trend: 1.195        
Probability: 0.116