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Study Information
Study Attribute Value
CEBS Accession Number: 002-02597-0002-0000-7
Chemical Name: Nitrofen
CASRN: 1836-75-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 363245_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 07/01/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Test Chemical: Nitrofen 
1000         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
1600         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
3000         
 200 4 0.020 2.0 1 0.005 0.5 3 0.015 1.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 39 0.195 16.0 14 0.070 6.0 25 0.125 11.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 20 0.400 36.0 14 0.280 28.0 6 0.120 10.0 0 0.000 0.0
Trend: 0.527 0.767 0.163  
Probability: 0.299 0.221 0.435  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 07/01/1987    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Nitrofen 
1000         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
1600         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
3000         
 110 2 0.018 1.8 1 0.009 0.9 1 0.009 0.9 0 0.000 0.0 
5000         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 35 0.175 14.5 10 0.050 5.0 25 0.125 10.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 21 0.420 32.0 9 0.180 16.0 12 0.240 22.0 0 0.000 0.0
Trend: -0.093 0.565 -0.513  
Probability: 0.537 0.286 0.696