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Study Information
Study Attribute Value
CEBS Accession Number: 002-02598-0001-0000-7
Chemical Name: Nitrofurantoin
CASRN: 67-20-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 161709_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Questionable 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 03/11/1986    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1023 493 0.482 9.86 26.0 0.000
Test Chemical Nitrofurantoin 
3.3       
 50 1007 487 0.484 9.74 32.0 0.353 
10         
 50 1026 489 0.477 9.78 32.0 -1.101 
33.3       
 50 1011 583 0.577 11.66 32.0 19.659 
100         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1027 597 0.581 11.94 26.0 20.624
Mitomycin-C 
 0.01      
 5 103 144 1.398 28.80 26.0 190.104
Trend: 2.810        
Probability: 0.002        

Trial #: 2    Activation: No Activation    Date: 04/01/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1012 455 0.450 9.10 26.0 0.000
Test Chemical Nitrofurantoin 
10         
 50 1000 532 0.532 10.64 31.5 18.326 
25         
 50 1006 623 0.619 12.46 31.5 37.740 
33         
 50 1020 774 0.759 15.48 31.5 68.776 
50         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1013 602 0.594 12.04 26.0 32.177
Mitomycin-C 
 0.01      
 5 101 153 1.515 30.60 26.0 236.930
Trend: 9.063        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/11/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1018 483 0.474 9.66 26.0 0.000
Test Chemical Nitrofurantoin 
33         
 50 1006 483 0.480 9.66 32.0 1.193 
100         
 50 1001 528 0.527 10.56 32.0 11.173 
333         
 50 1016 602 0.593 12.04 32.0 24.883 
1000         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1033 673 0.652 13.46 26.0 37.314
Cyclophosphamide 
2         
 5 104 178 1.712 35.60 26.0 260.734
Trend: 3.986        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 04/01/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1020 457 0.448 9.14 26.0 0.000
Test Chemical Nitrofurantoin 
330         
 50 1028 498 0.484 9.96 31.5 8.124 
500         
 50 1017 526 0.517 10.52 31.5 15.438 
750         
 50 1001 634 0.633 12.68 31.5 41.364 
1000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1029 649 0.631 12.98 26.0 40.771
Cyclophosphamide 
2         
 5 101 150 1.485 30.00 26.0 231.477
Trend: 5.815        
Probability: 0.000