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Study Information
Study Attribute Value
CEBS Accession Number: 002-02598-0002-0000-8
Chemical Name: Nitrofurantoin
CASRN: 67-20-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 161709_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 04/22/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide
0         
200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Nitrofurantoin
10         
200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
25         
200 5 0.025 2.5 4 0.020 2.0 1 0.005 0.5 0 0.000 0.0
50         
200 9 0.045 4.5 3 0.015 1.5 6 0.030 3.0 0 0.000 0.0
75         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.05      
200 44 0.220 18.5 27 0.135 12.5 17 0.085 7.0 0 0.000 0.0
Mitomycin-C
 0.08      
25 25 1.000 60.0 11 0.440 40.0 14 0.560 36.0 0 0.000 0.0
Trend: 2.941 1.667 2.469  
Probability: 0.002 0.048 0.007  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/13/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Nitrofurantoin
747         
100 10 0.100 8.0 4 0.040 4.0 6 0.060 5.0 0 0.000 0.0
900         
100 23 0.230 17.0 11 0.110 11.0 12 0.120 10.0 0 0.000 0.0
950         
100 33 0.330 16.0 15 0.150 9.0 18 0.180 12.0 0 0.000 0.0
1000         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
6.25      
100 15 0.150 13.0 5 0.050 5.0 10 0.100 9.0 0 0.000 0.0
Cyclophosphamide
12.5       
25 12 0.480 40.0 4 0.160 16.0 8 0.320 24.0 0 0.000 0.0
Trend: 3.868 3.442 3.052  
Probability: 0.000 0.000 0.001  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 04/22/1986    Harvest Time: 20 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Nitrofurantoin
250         
200 4 0.020 2.0 3 0.015 1.5 1 0.005 0.5 0 0.000 0.0
500         
200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
750         
200 17 0.085 5.5 3 0.015 1.5 14 0.070 5.0 0 0.000 0.0
1000         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
6.25      
200 10 0.050 4.0 4 0.020 2.0 6 0.030 2.5 0 0.000 0.0
Cyclophosphamide
12.5       
25 7 0.280 28.0 6 0.240 24.0 1 0.040 4.0 0 0.000 0.0
Trend: 2.773 0.883 3.240  
Probability: 0.003 0.189 0.001