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Study Information
Study Attribute Value
CEBS Accession Number: 002-02598-0002-0000-8
Chemical Name: Nitrofurantoin
CASRN: 67-20-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 161709_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 04/22/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Nitrofurantoin 
10         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
25         
 200 5 0.025 2.5 4 0.020 2.0 1 0.005 0.5 0 0.000 0.0 
50         
 200 9 0.045 4.5 3 0.015 1.5 6 0.030 3.0 0 0.000 0.0 
75         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 44 0.220 18.5 27 0.135 12.5 17 0.085 7.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 25 1.000 60.0 11 0.440 40.0 14 0.560 36.0 0 0.000 0.0
Trend: 2.941 1.667 2.469  
Probability: 0.002 0.048 0.007  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/13/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Nitrofurantoin 
747         
 100 10 0.100 8.0 4 0.040 4.0 6 0.060 5.0 0 0.000 0.0 
900         
 100 23 0.230 17.0 11 0.110 11.0 12 0.120 10.0 0 0.000 0.0 
950         
 100 33 0.330 16.0 15 0.150 9.0 18 0.180 12.0 0 0.000 0.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 100 15 0.150 13.0 5 0.050 5.0 10 0.100 9.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 12 0.480 40.0 4 0.160 16.0 8 0.320 24.0 0 0.000 0.0
Trend: 3.868 3.442 3.052  
Probability: 0.000 0.000 0.001  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 04/22/1986    Harvest Time: 20 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Nitrofurantoin 
250         
 200 4 0.020 2.0 3 0.015 1.5 1 0.005 0.5 0 0.000 0.0 
500         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
750         
 200 17 0.085 5.5 3 0.015 1.5 14 0.070 5.0 0 0.000 0.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 10 0.050 4.0 4 0.020 2.0 6 0.030 2.5 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 7 0.280 28.0 6 0.240 24.0 1 0.040 4.0 0 0.000 0.0
Trend: 2.773 0.883 3.240  
Probability: 0.003 0.189 0.001