Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02598-0002-0000-8 |
Chemical Name: | Nitrofurantoin |
CASRN: | 67-20-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 161709_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Induced Rat Liver S9 | 2_S9 | Weakly Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Nitrofurantoin | 10 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
25 | 200 | 5 | 0.025 | 2.5 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
50 | 200 | 9 | 0.045 | 4.5 | 3 | 0.015 | 1.5 | 6 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | ||
75 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 200 | 44 | 0.220 | 18.5 | 27 | 0.135 | 12.5 | 17 | 0.085 | 7.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.08 | 25 | 25 | 1.000 | 60.0 | 11 | 0.440 | 40.0 | 14 | 0.560 | 36.0 | 0 | 0.000 | 0.0 | |
Trend: | 2.941 | 1.667 | 2.469 | ||||||||||||
Probability: | 0.002 | 0.048 | 0.007 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Nitrofurantoin | 747 | 100 | 10 | 0.100 | 8.0 | 4 | 0.040 | 4.0 | 6 | 0.060 | 5.0 | 0 | 0.000 | 0.0 |
900 | 100 | 23 | 0.230 | 17.0 | 11 | 0.110 | 11.0 | 12 | 0.120 | 10.0 | 0 | 0.000 | 0.0 | ||
950 | 100 | 33 | 0.330 | 16.0 | 15 | 0.150 | 9.0 | 18 | 0.180 | 12.0 | 0 | 0.000 | 0.0 | ||
1000 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 6.25 | 100 | 15 | 0.150 | 13.0 | 5 | 0.050 | 5.0 | 10 | 0.100 | 9.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 12.5 | 25 | 12 | 0.480 | 40.0 | 4 | 0.160 | 16.0 | 8 | 0.320 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | 3.868 | 3.442 | 3.052 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.001 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | Nitrofurantoin | 250 | 200 | 4 | 0.020 | 2.0 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
500 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
750 | 200 | 17 | 0.085 | 5.5 | 3 | 0.015 | 1.5 | 14 | 0.070 | 5.0 | 0 | 0.000 | 0.0 | ||
1000 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 6.25 | 200 | 10 | 0.050 | 4.0 | 4 | 0.020 | 2.0 | 6 | 0.030 | 2.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 12.5 | 25 | 7 | 0.280 | 28.0 | 6 | 0.240 | 24.0 | 1 | 0.040 | 4.0 | 0 | 0.000 | 0.0 | |
Trend: | 2.773 | 0.883 | 3.240 | ||||||||||||
Probability: | 0.003 | 0.189 | 0.001 |