Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02598-0016-0000-3 |
Chemical Name: | Nitrofurantoin |
CASRN: | 67-20-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 922322 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 126r | 108 | 136 | 36 | 35 |
129r | 120 | 170 | 44 | ||||
108 | 84 | 119 | 37 | ||||
108 | 116 | 110 | 34 | ||||
Test Chemical | Nitrofurantoin | 50 | 99 | 60 | 152 | 51 | 54 |
87 | 71 | 149 | 57 | ||||
84 | 64 | 134 | 53 | ||||
100 | 84 | 39 | 272 | 108 | 101* | ||
70 | 44 | 207 | 99 | ||||
90# | 51 | 257 | 96 | ||||
150 | 71 | 26 | 430 | 203 | 196* | ||
102 | 25 | 658 | 216 | ||||
65 | 29 | 330 | 170 | ||||
200 | 75 | 19 | 598 | 268 | 194* | ||
66 | 26 | 236 | 120 | ||||
300 | 57 | 13 | 516 | 302 | 292* | ||
73 | 14 | 669 | 306 | ||||
72 | 18 | 575 | 268 | ||||
500 | 62 | 10 | 544 | 292 | 298* | ||
49 | 8 | 406 | 277 | ||||
52 | 9 | 507 | 324 | ||||
Positive Control | Methyl Methane Sulfonate | 5 | 81 | 57 | 690 | 285 | 285* |
89 | 60 | 731 | 275 | ||||
71 | 52 | 631 | 296 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 86 | 114 | 80 | 31 | 25 |
86 | 97 | 74 | 29 | ||||
85 | 85 | 45 | 18 | ||||
79 | 104 | 55 | 23 | ||||
Test Chemical | Nitrofurantoin | 50 | 87 | 61 | 69 | 26 | 40* |
93 | 64 | 155 | 56 | ||||
74 | 70 | 84 | 38 | ||||
100 | 77 | 37 | 184 | 80 | 60* | ||
75 | 41 | 155 | 69 | ||||
73 | 49 | 73 | 33 | ||||
150 | 62 | 26 | 91 | 49 | 78* | ||
65 | 28 | 181 | 93 | ||||
56 | 29 | 155 | 93 | ||||
200 | 50 | 17 | 312 | 207 | 144* | ||
48 | 11 | 172 | 121 | ||||
81 | 17 | 252 | 104 | ||||
300 | 35 | 8 | 239 | 229 | 271* | ||
48 | 7 | 369 | 256 | ||||
29 | 4 | 283 | 327 | ||||
500 | 25 | 2 | 77 | 103 | 374* | ||
16 | 2 | 204 | 439 | ||||
17# | 2 | 287 | 580 | ||||
Positive Control | Methyl Methane Sulfonate | 5 | 46 | 38 | 261 | 188 | 149* |
67 | 50 | 274 | 137 | ||||
57 | 44 | 208 | 122 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination