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Study Information
Study Attribute Value
CEBS Accession Number: 002-02599-0001-0000-8
Chemical Name: Nitrofurazone
CASRN: 59-87-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 356548_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/27/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 554 0.529 11.08 26.0 0.000
Test Chemical Nitrofurazone 
 0.25      
 50 1049 667 0.636 13.34 26.0 20.282 
 0.83      
 50 1043 717 0.687 14.34 26.0 30.043 
2.5       
 50 1048 713 0.680 14.26 26.0 28.700 
8.33      
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1048 810 0.773 16.20 26.0 46.209
Mitomycin-C 
 0.01      
 5 105 249 2.371 49.80 26.0 348.602
Trend: 4.638        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/20/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 544 0.519 10.88 26.0 0.000
Test Chemical Nitrofurazone 
10         
 50 1049 864 0.824 17.28 34.3 58.672 
12.5       
 50 1046 1033 0.988 20.66 34.3 90.253 
15         
 50 1047 1052 1.005 21.04 34.3 93.567
Positive Control Mitomycin-C 
 0.0015    
 50 1047 844 0.806 16.88 26.0 55.295
Mitomycin-C 
 0.01      
 5 105 309 2.943 61.80 26.0 466.933
Trend: 12.954        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/27/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 497 0.478 9.94 26.0 0.000
Test Chemical Nitrofurazone 
25         
 50 1043 558 0.535 11.16 26.0 11.951 
83.3       
 50 1047 610 0.583 12.20 26.0 21.916 
250         
 50 1045 697 0.667 13.94 26.0 39.570 
833         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1047 732 0.699 14.64 26.0 46.299
Cyclophosphamide 
2         
 5 105 158 1.505 31.60 26.0 214.880
Trend: 5.889        
Probability: 0.000