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Study Information
Study Attribute Value
CEBS Accession Number: 002-02599-0002-0000-9
Chemical Name: Nitrofurazone
CASRN: 59-87-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 356548_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Questionable 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 08/01/1984    Harvest Time: 18.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Nitrofurazone 
20         
 100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 
23         
 100 21 0.210 17.0 5 0.050 3.0 15 0.150 15.0 1 0.010 1.0 
25         
 25 13 0.520 24.0 2 0.080 8.0 11 0.440 20.0 0 0.000 0.0 
30         
 25 9 0.360 28.0 2 0.080 8.0 6 0.240 24.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 16 0.160 14.0 4 0.040 4.0 12 0.120 12.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 100 31 0.310 21.0 13 0.130 9.0 18 0.180 15.0 0 0.000 0.0
Trend: 5.097 2.750 4.884  
Probability: 0.000 0.003 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/01/1984    Harvest Time: 18.5 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Nitrofurazone 
300         
 100 5 0.050 4.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0 
400         
 100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 
500         
 100 4 0.040 2.0 2 0.020 1.0 2 0.020 2.0 0 0.000 0.0 
600         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
3.8       
 100 5 0.050 5.0 2 0.020 2.0 3 0.030 3.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 7 0.280 16.0 4 0.160 16.0 3 0.120 12.0 0 0.000 0.0
Trend: 0.978 0.764 0.819  
Probability: 0.164 0.222 0.207  


Trial #:2   Activation: No Activation    Date: 09/05/1984    Harvest Time: 18.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Nitrofurazone 
25         
 100 19 0.190 17.0 5 0.050 4.0 14 0.140 14.0 0 0.000 0.0 
30         
 100 22 0.220 19.0 3 0.030 3.0 18 0.180 16.0 1 0.010 1.0 
40         
 50 56 1.120 44.0 5 0.100 10.0 31 0.620 32.0 20 0.400 2.0
Positive Control: Mitomycin-C 
 0.04      
 100 33 0.330 24.0 15 0.150 13.0 18 0.180 13.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 14 0.560 40.0 8 0.320 24.0 6 0.240 20.0 0 0.000 0.0
Trend: 6.224 2.869 4.987  
Probability: 0.000 0.002 0.000