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Study Information
Study Attribute Value
CEBS Accession Number: 002-02601-0001-0000-2
Chemical Name: Nitromethane
CASRN: 75-52-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 703142_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/10/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1048 349 0.333 6.98 26.0 0.000
Test Chemical Nitromethane 
497         
 50 1049 374 0.357 7.48 26.0 7.061 
1655         
 50 1049 394 0.376 7.88 26.0 12.786 
4965         
 50 1052 411 0.391 8.22 26.0 17.317
Positive Control Mitomycin-C 
 0.001     
 50 1050 534 0.509 10.68 26.0 52.717
Mitomycin-C 
 0.004     
 10 209 186 0.890 18.60 26.0 167.241
Trend: 2.308        
Probability: 0.010        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/10/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1053 428 0.406 8.56 26.0 0.000
Test Chemical Nitromethane 
497         
 50 1050 407 0.388 8.14 26.0 -4.635 
1655         
 50 1052 383 0.364 7.66 26.0 -10.429 
4965         
 50 1051 381 0.363 7.62 26.0 -10.812
Positive Control Cyclophosphamide 
 0.125     
 50 1051 647 0.616 12.94 26.0 51.456
Cyclophosphamide 
 0.5       
 10 210 241 1.148 24.10 26.0 182.346
Trend: -1.837        
Probability: 0.967