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Study Information
Study Attribute Value
CEBS Accession Number: 002-02606-0001-0000-7
Chemical Name: Ochratoxin A
CASRN: 303-47-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 943337_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/10/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 427 0.407 8.54 26.0 0.000
Test Chemical Ochratoxin A 
 0.5       
 50 1049 444 0.423 8.88 26.0 3.882 
1.6       
 50 1050 448 0.427 8.96 26.0 4.718 
5         
 35 733 297 0.405 8.49 26.0 -0.554
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 569 0.542 11.38 26.0 33.001
Mitomycin-C 
 0.005     
 10 209 329 1.574 32.90 26.0 286.352
Trend: 0.085        
Probability: 0.466        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/18/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 424 0.403 8.48 26.0 0.000
Test Chemical Ochratoxin A 
5         
 50 1050 470 0.448 9.40 26.0 10.955 
16         
 50 1050 514 0.490 10.28 26.0 21.342 
50         
 50 1049 558 0.532 11.16 26.0 31.855 
160         
 50 1050 564 0.537 11.28 26.0 33.146 
500         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.1       
 50 1049 604 0.576 12.08 26.0 42.724
Cyclophosphamide 
 0.6       
 10 210 246 1.171 24.60 26.0 190.371
Trend: 5.192        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/30/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 437 0.417 8.74 26.0 0.000
Test Chemical Ochratoxin A 
30         
 50 1049 462 0.440 9.24 26.0 5.721 
50         
 50 1049 504 0.480 10.08 26.0 15.332 
100         
 50 1050 525 0.500 10.50 26.0 20.023 
160         
 50 1049 597 0.569 11.94 26.0 36.613 
300         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.1       
 50 1051 547 0.520 10.94 26.0 24.933
Cyclophosphamide 
 0.6       
 10 210 265 1.262 26.50 26.0 202.915
Trend: 5.333        
Probability: 0.000