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Study Information
Study Attribute Value
CEBS Accession Number: 002-02606-0002-0000-8
Chemical Name: Ochratoxin A
CASRN: 303-47-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 943337_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/23/1986    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Ochratoxin A 
30         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
50         
 42 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
100         
 200 4 0.020 1.5 2 0.010 1.0 2 0.010 0.5 0 0.000 0.0 
160         
 186 5 0.027 2.7 0 0.000 0.0 5 0.027 2.7 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 52 0.260 22.0 25 0.125 10.5 27 0.135 12.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 21 0.420 34.0 11 0.220 20.0 10 0.200 18.0 0 0.000 0.0
Trend: 1.940 1.051 1.639  
Probability: 0.026 0.147 0.051  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/23/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: Ochratoxin A 
100         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
160         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
300         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 34 0.170 16.5 8 0.040 4.0 26 0.130 13.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 49 0.980 56.0 9 0.180 18.0 30 0.600 46.0 10 0.200 1.0
Trend: 0.368 -1.327 0.897  
Probability: 0.356 0.908 0.185