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Study Information
Study Attribute Value
CEBS Accession Number: 002-02615-0016-0000-3
Chemical Name: Oleic acid diethanolamine condensate
CASRN: 93-83-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 932123
Study Result: Negative


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 96 107 116 40 35
    116 95 97 28
    121r 106 106 29
    107 99 120 38
Test Chemical Oleic acid diethanolamine condensate 
1.25      
 115 87 112 33 34
    104 80 137 44
    111 75 84 25
  
2.5       
 118 53 109 31 34
    117 63 152 43
    98 60 86 29
  
5         
 104 23 139 45 37
    119 56 85 24
    110 39 141 43
  
7.5       
   
   
Positive Control Methyl Methane Sulfonate 
5         
 57 15 639 372 618*
    34 11 731 724
    31 9 709 758

Nonactivation Trial: 2 Experiment Call: Inconclusive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 114 114 95 28 27
    112 88 99 29
    116 100 88 25
    108 98 87 27
Test Chemical Oleic acid diethanolamine condensate 
2         
 106 100 72 23 26
    107 107 90 28
    105 75 83 26
  
3         
 118 140 68 19 18
    116 73 62 18
    115 102 59 17
  
4         
 113 117 66 19 22
    112 86 66 20
    114 79 89 26
  
6         
 122r 85 87 24 21
    117 70 75 21
    113 75 72 21
  
8         
 107 76 88 27 26
    116 56 81 23
    107 46 89 28
  
12         
 109 51 71 22 22
    116 81 77 22
    121r 60 98 27
Positive Control Methyl Methane Sulfonate 
5         
 87 56 668 256 294*
    69 47 611 297
    69 42 682 329

Nonactivation Trial: 3 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 104 170 92 29 25
    120 124 92 26
    115 69 81 23
    105 36 67 21
Test Chemical Oleic acid diethanolamine condensate 
3         
 98 121 61 21 21
    103 90 57 18
    107 130 78 24
  
4         
 109 107 88 27 24
    110 115 80 24
    109 131 66 20
  
6         
 107 113 87 27 26
    105 118 89 28
    98 45 67 23
  
8         
 110 60 97 30 26
    100 88 79 26
    106 62 69 22
  
15         
 117# 16 112 32 28
    118 67 70 20
    105 59 99 31
Positive Control Methyl Methane Sulfonate 
5         
 90 70 546 203 203*
    71 20 453 213
    87 74 506 194

Induced S9 Trial: 1 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 116 103 204 59 46
    119# 119 128 36
    127r 138 200 53
    89 78 113 42
Test Chemical Oleic acid diethanolamine condensate 
2.5       
 107 82 136 42 56
    118 82 230 65
    93# 81 169 60
  
5         
 113 84 281 83 62
    93# 81 151 54
    109 115 158 48
  
7.5       
 109 103 154 47 51
    102# 91 169 55
  
10         
 129r 76 140 36 46
    89 16 108 40
    85# 19 133.5 52
Positive Control 3-Methylcholanthrene 
2.5       
 103 47 998 323 329*
    81# 44 900 370
    112 45 986 293

Induced S9 Trial: 2 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 26
    113 115 85 25
    115 77 73 21
    76# 108 74 33
Test Chemical Oleic acid diethanolamine condensate 
2.5       
 112 80 90 27 25
    114 137 81 24
    76 22 54 24
  
5         
 115 108 59 17 18
    85 83 50 20
    112 110 56 17
  
7.5       
 108 32 95 29 24
    113 59 91 27
    106 93 46 15
  
10         
 106 134 74 23 25
    105 85 68 22
    111 56 105 32
  
15         
 107 46 87 27 24
   
    101 104 66 22
  
20         
   
   
Positive Control 3-Methylcholanthrene 
2.5       
 68 19 534 262 220*
    107 68 568 177

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination