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Study Information
Study Attribute Value
CEBS Accession Number: 002-02622-0001-0000-5
Chemical Name: Oxazepam
CASRN: 604-75-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 785473_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 08/01/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 424 0.404 8.48 26.0 7.477
Dimethyl Sulfoxide 
0         
 50 1045 393 0.376 7.86 31.0 0.000
Test Chemical Oxazepam 
5         
 50 1048 448 0.427 8.96 26.0 13.669 
17         
 50 1048 428 0.408 8.56 26.0 8.594 
50         
 50 1048 449 0.428 8.98 31.0 13.922 
167         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1048 579 0.552 11.58 26.0 46.907
Mitomycin-C 
 0.004     
 10 210 223 1.062 22.30 26.0 182.364
Trend: 1.550        
Probability: 0.061        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/01/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 413 0.393 8.26 26.0 2.345
Dimethyl Sulfoxide 
0         
 50 1046 402 0.384 8.04 26.0 0.000
Test Chemical Oxazepam 
5         
 50 1048 452 0.431 9.04 26.0 12.223 
17         
 50 1050 460 0.438 9.20 26.0 13.992 
50         
 50 1048 445 0.425 8.90 26.0 10.485 
167         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1043 579 0.555 11.58 26.0 44.444
Cyclophosphamide 
 0.5       
 10 209 205 0.981 20.50 26.0 155.219
Trend: 1.448        
Probability: 0.074