COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02625-0001-0000-8
Chemical Name: Oxytetracycline hydrochloride
CASRN: 2058-46-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 604406_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/22/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1046 436 0.417 8.72 26.0 0.000
Test Chemical Oxytetracycline hydrochloride 
 0.5       
 50 1034 420 0.406 8.40 26.0 -2.552 
1.6       
 50 1037 475 0.458 9.50 26.0 9.890 
5         
 50 1044 447 0.428 8.94 26.0 2.719 
16         
 50 1042 427 0.410 8.54 26.0 -1.688 
50         
 36 746 255 0.342 7.08 26.0 -17.994
Positive Control Mitomycin-C 
 0.0E-4    
 50 1046 616 0.589 12.32 26.0 41.284
Mitomycin-C 
 0.005     
 10 210 291 1.386 29.10 26.0 232.444
Trend: -1.848        
Probability: 0.968        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/22/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 483 0.463 9.66 26.0 0.000
Test Chemical Oxytetracycline hydrochloride 
16         
 50 1046 411 0.393 8.22 26.0 -15.070 
50         
 50 1045 433 0.414 8.66 26.0 -10.438 
160         
 50 1044 465 0.445 9.30 26.0 -3.727 
500         
 50 1044 465 0.445 9.30 26.0 -3.727
Positive Control Cyclophosphamide 
 0.15      
 50 1045 615 0.589 12.30 26.0 27.207
Cyclophosphamide 
 0.6       
 10 210 197 0.938 19.70 26.0 102.768
Trend: 0.284        
Probability: 0.388