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Study Information
Study Attribute Value
CEBS Accession Number: 002-02625-0002-0000-9
Chemical Name: Oxytetracycline hydrochloride
CASRN: 2058-46-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 682810_SCE
Study Result: Not a Valid Test

Study Result: Not a Valid Test
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Test Failure 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Test Failure 

Trial #: 1    Activation: No Activation    Date: 02/23/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1046 546 0.522 10.92 25.5 0.000
Test Chemical Oxytetracycline hydrochloride 
60         
 50 1046 647 0.619 12.94 35.5 18.498 
70         
 50 1046 676 0.646 13.52 35.5 23.810 
80         
 50 1036 637 0.615 12.74 35.5 17.793
Positive Control Mitomycin-C 
 0.001     
 50 1047 886 0.846 17.72 25.5 62.116
Mitomycin-C 
 0.01      
 5 104 282 2.712 56.40 0.0 419.463
Trend: 2.901        
Probability: 0.002        

Trial #: 2    Activation: No Activation    Date: 03/15/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1041 450 0.432 9.00 25.7 0.000
Test Chemical Oxytetracycline hydrochloride 
5         
 50 1046 548 0.524 10.96 25.7 21.196 
10         
 50 1043 530 0.508 10.60 25.7 17.552 
50         
 50 1047 639 0.610 12.78 34.0 41.186 
100         
 0 0 0 0.000 0.00 34.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1047 659 0.629 13.18 25.7 45.605
Mitomycin-C 
 0.01      
 5 105 206 1.962 41.20 25.7 353.854
Trend: 5.411        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/15/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1048 619 0.591 12.38 25.7 0.000
Test Chemical Oxytetracycline hydrochloride 
100         
 50 1042 582 0.559 11.64 25.7 -5.436 
500         
 0 0 0 0.000 0.00 34.0 N/A
Positive Control Cyclophosphamide 
2         
 5 104 248 2.385 49.60 25.7 303.728
Trend: -0.968        
Probability: 0.834        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/23/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1052 680 0.646 13.60 25.5 0.000
Test Chemical Oxytetracycline hydrochloride 
400         
 50 1037 802 0.773 16.04 35.5 19.647 
500         
 26 530 431 0.813 16.58 35.5 25.808 
700         
 47 978 826 0.845 17.57 35.5 30.662
Positive Control Cyclophosphamide 
 0.35      
 50 1049 922 0.879 18.44 25.5 35.976
Cyclophosphamide 
2         
 5 106 172 1.623 34.40 25.5 151.032
Trend: 5.047        
Probability: 0.000