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Study Information
Study Attribute Value
CEBS Accession Number: 002-02625-0003-0000-0
Chemical Name: Oxytetracycline hydrochloride
CASRN: 2058-46-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 682810_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 04/27/1983    Harvest Time: 22.3 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 0 0.000 0.0 1 0.010 1.0 2 0.020 2.0
Water 
0         
 100 6 0.060 6.0 2 0.020 2.0 1 0.010 1.0 3 0.030 3.0
Test Chemical: Oxytetracycline hydrochloride 
80         
 100 4 0.040 3.0 1 0.010 1.0 1 0.010 1.0 2 0.020 2.0 
90         
 100 5 0.050 4.0 0 0.000 0.0 2 0.020 2.0 3 0.030 3.0 
100         
 100 5 0.050 4.0 1 0.010 1.0 1 0.010 1.0 3 0.030 3.0
Positive Control: Mitomycin-C 
 0.05      
 50 56 1.120 52.0 34 0.680 42.0 22 0.440 32.0 0 0.000 0.0
Trend: -0.554 -0.919 0.217  
Probability: 0.710 0.821 0.414  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/27/1983    Harvest Time: 22.3 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 1 0.010 1.0 2 0.020 2.0 1 0.010 1.0
Water 
0         
 100 4 0.040 3.0 0 0.000 0.0 3 0.030 2.0 1 0.010 1.0
Test Chemical: Oxytetracycline hydrochloride 
700         
 100 5 0.050 5.0 1 0.010 1.0 2 0.020 2.0 2 0.020 2.0 
800         
 100 4 0.040 4.0 1 0.010 1.0 1 0.010 1.0 2 0.020 2.0 
900         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 44 0.880 58.0 24 0.480 40.0 18 0.360 32.0 2 0.040 2.0
Trend: -0.113 0.781 -0.185  
Probability: 0.545 0.218 0.574