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Study Information
Study Attribute Value
CEBS Accession Number: 002-02634-0001-0000-8
Chemical Name: Penicillin VK
CASRN: 132-98-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 130786_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 11/06/1990    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Solvent 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: Penicillin VK 
1000         
 200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
1600         
 200 5 0.025 2.0 2 0.010 1.0 3 0.015 1.0 0 0.000 0.0 
3000         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
5000         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 45 0.225 18.0 17 0.085 7.0 27 0.135 11.0 1 0.005 1.0
Mitomycin-C 
 0.25      
 50 21 0.420 36.0 5 0.100 8.0 16 0.320 30.0 0 0.000 0.0
Trend: -0.476 -0.621 -0.024  
Probability: 0.683 0.733 0.510  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/06/1990    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Solvent 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Penicillin VK 
1000         
 200 6 0.030 2.0 0 0.000 0.0 6 0.030 2.0 0 0.000 0.0 
1600         
 200 3 0.015 1.5 0 0.000 0.0 2 0.010 1.0 1 0.005 1.0 
3000         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
5000         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 25 0.125 10.0 4 0.020 2.0 20 0.100 9.0 1 0.005 1.0
Cyclophosphamide 
7.5       
 50 17 0.340 32.0 7 0.140 14.0 10 0.200 18.0 0 0.000 0.0
Trend: -0.012 0.000 0.009  
Probability: 0.505 0.000 0.496