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Study Information
Study Attribute Value
CEBS Accession Number: 002-02634-0002-0000-9
Chemical Name: Penicillin VK
CASRN: 132-98-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 391874_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/03/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1035 526 0.508 10.52 26.0 0.000
Test Chemical Penicillin VK 
500         
 50 1037 538 0.519 10.76 26.0 2.084 
1667         
 50 1037 546 0.527 10.92 26.0 3.602 
5000         
 50 1029 759 0.738 15.18 26.0 45.138
Positive Control Mitomycin-C 
 0.0015    
 50 1036 828 0.799 16.56 26.0 57.263
Mitomycin-C 
 0.01      
 5 103 282 2.738 56.40 26.0 438.724
Trend: 6.526        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/19/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1046 468 0.447 9.36 26.5 0.000
Test Chemical Penicillin VK 
5000         
 50 1045 716 0.685 14.32 26.5 53.138 
6000         
 50 1047 812 0.776 16.24 36.5 73.339 
7000         
 50 1044 831 0.796 16.62 36.5 77.904 
8000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1042 771 0.740 15.42 26.5 65.376
Mitomycin-C 
 0.01      
 5 104 217 2.087 43.40 26.5 366.350
Trend: 9.979        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/03/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1035 544 0.526 10.88 26.0 0.000
Test Chemical Penicillin VK 
500         
 50 1043 610 0.585 12.20 26.0 11.272 
1667         
 50 1038 513 0.494 10.26 26.0 -5.971 
5000         
 50 1031 564 0.547 11.28 26.0 4.079
Positive Control Cyclophosphamide 
 0.4       
 50 1041 791 0.760 15.82 26.0 44.566
Cyclophosphamide 
2         
 5 105 169 1.610 33.80 26.0 206.224
Trend: -0.302        
Probability: 0.619        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/19/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1050 524 0.499 10.48 26.5 0.000
Test Chemical Penicillin VK 
8000         
 50 1046 504 0.482 10.08 26.5 -3.449 
9000         
 50 1047 513 0.490 10.26 26.5 -1.819 
10000         
 50 1049 509 0.485 10.18 26.5 -2.770
Positive Control Cyclophosphamide 
 0.4       
 50 1049 753 0.718 15.06 26.5 43.839
Cyclophosphamide 
2         
 5 104 186 1.788 37.20 26.5 258.375
Trend: -0.343        
Probability: 0.634