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Study Information
Study Attribute Value
CEBS Accession Number: 002-02634-0003-0000-0
Chemical Name: Penicillin VK
CASRN: 132-98-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 391874_CA
Study Result: Not a Valid Test

Study Result: Not a Valid Test
Activation Trial Trial Call
No Activation  1  Test Failure 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Test Failure 

Trial #:1   Activation: No Activation    Date: 07/17/1984    Harvest Time: 22 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Medium 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Penicillin VK 
9000         
 50 108 2.160 42.0 4 0.080 8.0 44 0.880 58.0 60 1.200 12.0 
9500         
 50 109 2.180 50.0 1 0.020 2.0 48 0.960 36.0 60 1.200 12.0 
10000         
 50 95 1.900 50.0 5 0.100 10.0 59 1.180 36.0 31 0.620 8.0
Positive Control: Mitomycin-C 
 0.025     
 100 25 0.250 18.0 17 0.170 12.0 8 0.080 8.0 0 0.000 0.0
Mitomycin-C 
 0.063     
 50 41 0.820 52.0 22 0.440 36.0 19 0.380 26.0 0 0.000 0.0
Trend: 6.977 1.660 5.070  
Probability: 0.000 0.048 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 07/18/1984    Harvest Time: 11 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Penicillin VK 
9000         
 100 3 0.030 2.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
9500         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
10000         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
7.5       
 100 11 0.110 10.0 4 0.040 1.0 7 0.070 6.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 50 34 0.680 38.0 13 0.260 26.0 11 0.220 16.0 10 0.200 1.0
Trend: 0.362 -0.452 -0.203  
Probability: 0.359 0.675 0.581  


Trial #:2   Activation: No Activation    Date: 07/25/1984    Harvest Time: 21.5 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 50 1 0.020 2.0 1 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Medium 
0         
 50 2 0.040 4.0 1 0.020 2.0 1 0.020 2.0 0 0.000 0.0
Test Chemical: Penicillin VK 
9000         
 50 18 0.360 20.0 4 0.080 8.0 14 0.280 18.0 0 0.000 0.0 
9500         
 25 77 3.080 64.0 3 0.120 12.0 14 0.560 32.0 60 2.400 6.0 
10000         
 25 28 1.120 40.0 5 0.200 20.0 13 0.520 28.0 10 0.400 1.0
Positive Control: Mitomycin-C 
 0.025     
 50 9 0.180 16.0 5 0.100 8.0 4 0.080 8.0 0 0.000 0.0
Mitomycin-C 
 0.063     
 25 23 0.920 48.0 10 0.400 3.2 13 0.520 32.0 0 0.000 0.0
Trend: 4.896 2.671 3.465  
Probability: 0.000 0.004 0.000