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Study Information
Study Attribute Value
CEBS Accession Number: 002-02640-0001-0000-5
Chemical Name: Pentachloroanisole
CASRN: 1825-21-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 259382_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Test Failure 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/30/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1040 517 0.497 10.34 25.8 -26.486
Dimethyl Sulfoxide 
0         
 50 1047 708 0.676 14.16 25.8 0.000
Test Chemical Pentachloroanisole 
11.7       
 50 1042 587 0.563 11.74 25.8 -16.693 
35         
 50 1042 616 0.591 12.32 34.0 -12.577 
117         
 50 1035 707 0.683 14.14 34.0 1.017
Positive Control Mitomycin-C 
 0.001     
 50 1041 757 0.727 15.14 25.8 7.537
Mitomycin-C 
 0.01      
 5 103 195 1.893 39.00 25.8 179.970
Trend: 0.460        
Probability: 0.323        

Trial #: 2    Activation: No Activation    Date: 04/26/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 694 0.662 13.88 26.3 0.000
Negative (Not Specified) 
0         
 50 1044 572 0.548 11.44 26.3 -17.185
Test Chemical Pentachloroanisole 
75         
 36 744 475 0.638 13.19 26.3 -3.498 
100         
 50 1043 882 0.846 17.64 34.3 27.820 
125         
 50 1043 840 0.805 16.80 34.3 21.734
Positive Control Mitomycin-C 
 0.001     
 39 809 692 0.855 17.74 26.3 29.293
Mitomycin-C 
 0.01      
 5 106 236 2.226 47.20 26.3 236.529
Trend: 5.275        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/20/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 574 0.550 11.48 25.8 0.000
Test Chemical Pentachloroanisole 
117         
 50 1044 606 0.580 12.12 25.8 5.575 
350         
 50 1052 642 0.610 12.84 25.8 10.996 
700         
 50 1042 950 0.912 19.00 34.0 65.823
Positive Control Cyclophosphamide 
 0.35      
 50 1046 790 0.755 15.80 25.8 37.368
Cyclophosphamide 
2         
 5 104 187 1.798 37.40 25.8 227.037
Trend: 9.427        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 04/26/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 634 0.604 12.68 26.3 0.000
Test Chemical Pentachloroanisole 
595         
 50 1040 757 0.728 15.14 26.3 20.434 
648         
 50 1040 968 0.931 19.36 34.3 54.003 
700         
 50 1042 878 0.843 17.56 34.3 39.416
Positive Control Cyclophosphamide 
 0.35      
 50 1046 855 0.817 17.10 26.3 35.245
Cyclophosphamide 
2         
 5 105 193 1.838 38.60 26.3 204.126
Trend: 7.620        
Probability: 0.000