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Study Information
Study Attribute Value
CEBS Accession Number: 002-02641-0001-0000-6
Chemical Name: Pentachlorobenzene
CASRN: 608-93-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 710481_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/26/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 401 0.385 8.02 26.0 0.000
Test Chemical Pentachlorobenzene 
1.6       
 50 1044 432 0.414 8.64 26.0 7.524 
5.12      
 50 1044 452 0.433 9.04 26.0 12.502 
16         
 50 1047 434 0.415 8.68 26.0 7.713
Positive Control Mitomycin-C 
 0.005     
 25 521 509 0.977 20.36 26.0 153.865
Trend: 1.221        
Probability: 0.111        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/26/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 451 0.431 9.02 26.0 0.000
Test Chemical Pentachlorobenzene 
16         
 50 1044 388 0.372 7.76 26.0 -13.804 
51.2       
 50 1050 434 0.413 8.68 26.0 -4.136 
160         
 50 1045 488 0.467 9.76 26.0 8.308
Positive Control Cyclophosphamide 
1         
 50 1046 800 0.765 16.00 26.0 77.384
Trend: 1.657        
Probability: 0.049