COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02642-0001-0000-7
Chemical Name: Pentachloroethane
CASRN: 76-01-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 818137_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
No Activation  3  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 08/25/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1020 443 0.434 8.86 25.5 0.000
Test Chemical Pentachloroethane 
16.1       
 50 1029 422 0.410 8.44 25.5 -5.574 
53.7       
 50 1032 522 0.506 10.44 25.5 16.463 
161         
 50 1012 608 0.601 12.16 34.5 38.331 
537         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1040 674 0.648 13.48 25.5 49.219
Mitomycin-C 
 0.005     
 5 104 152 1.462 30.40 25.5 236.517
Trend: 6.054        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 09/01/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1019 425 0.417 8.50 25.5 0.000
Test Chemical Pentachloroethane 
50         
 50 1029 478 0.465 9.56 25.5 11.378 
100         
 50 1022 514 0.503 10.28 25.5 20.586 
150         
 50 1020 533 0.523 10.66 25.5 25.289 
200         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1025 659 0.643 13.18 25.5 54.151
Mitomycin-C 
 0.01      
 5 104 212 2.038 42.40 25.5 388.751
Trend: 3.676        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 10/05/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1022 412 0.403 8.24 25.5 0.000
Test Chemical Pentachloroethane 
72.5       
 50 1030 472 0.458 9.44 25.5 13.673 
115.8       
 50 1010 567 0.561 11.34 32.0 39.256 
144.9       
 50 1017 577 0.567 11.54 32.0 40.737
Positive Control Mitomycin-C 
 0.001     
 50 1028 635 0.618 12.70 25.5 53.227
Mitomycin-C 
 0.01      
 0 0 0 0.000 0.00 0.0 N/A
Trend: 6.216        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/02/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1007 450 0.447 9.00 25.5 0.000
Test Chemical Pentachloroethane 
101         
 50 1031 449 0.435 8.98 25.5 -2.545 
127         
 50 1012 490 0.484 9.80 25.5 8.351 
151         
 50 1018 449 0.441 8.98 31.5 -1.300 
172         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1004 563 0.561 11.26 25.5 25.485
Cyclophosphamide 
2         
 5 104 158 1.519 31.60 25.5 239.970
Trend: 0.422        
Probability: 0.336