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Study Information
Study Attribute Value
CEBS Accession Number: 002-02642-0001-0000-7
Chemical Name: Pentachloroethane
CASRN: 76-01-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 818137_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Weakly Positive 
No Activation  Positive 
No Activation  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 08/25/1982    Trial Call: Weakly Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1020 443 0.434 8.86 25.5 0.000
Test Chemical Pentachloroethane
16.1       
50 1029 422 0.410 8.44 25.5 -5.574
53.7       
50 1032 522 0.506 10.44 25.5 16.463
161         
50 1012 608 0.601 12.16 34.5 38.331
537         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C
 0.001     
50 1040 674 0.648 13.48 25.5 49.219
Mitomycin-C
 0.005     
5 104 152 1.462 30.40 25.5 236.517
Trend: 6.054        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 09/01/1982    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1019 425 0.417 8.50 25.5 0.000
Test Chemical Pentachloroethane
50         
50 1029 478 0.465 9.56 25.5 11.378
100         
50 1022 514 0.503 10.28 25.5 20.586
150         
50 1020 533 0.523 10.66 25.5 25.289
200         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C
 0.001     
50 1025 659 0.643 13.18 25.5 54.151
Mitomycin-C
 0.01      
5 104 212 2.038 42.40 25.5 388.751
Trend: 3.676        
Probability: 0.000        

Trial #: 3    Activation: No Activation    Date: 10/05/1982    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1022 412 0.403 8.24 25.5 0.000
Test Chemical Pentachloroethane
72.5       
50 1030 472 0.458 9.44 25.5 13.673
115.8       
50 1010 567 0.561 11.34 32.0 39.256
144.9       
50 1017 577 0.567 11.54 32.0 40.737
Positive Control Mitomycin-C
 0.001     
50 1028 635 0.618 12.70 25.5 53.227
Mitomycin-C
 0.01      
0 0 0 0.000 0.00 0.0 N/A
Trend: 6.216        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/02/1982    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1007 450 0.447 9.00 25.5 0.000
Test Chemical Pentachloroethane
101         
50 1031 449 0.435 8.98 25.5 -2.545
127         
50 1012 490 0.484 9.80 25.5 8.351
151         
50 1018 449 0.441 8.98 31.5 -1.300
172         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
 0.3       
50 1004 563 0.561 11.26 25.5 25.485
Cyclophosphamide
2         
5 104 158 1.519 31.60 25.5 239.970
Trend: 0.422        
Probability: 0.336