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Study Information
Study Attribute Value
CEBS Accession Number: 002-02642-0006-0000-2
Chemical Name: Pentachloroethane
CASRN: 76-01-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 072127
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Inconclusive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 85 99 124 48 54
    82 101 118 48
    78 113 121 52
    63 87 130 69
Test Chemical Pentachloroethane 
6.25      
 82 116 109 44 40
    87 118 95 36
  
12.5       
 95 103 163 57 48
    82 114 94 38
  
25         
 84 110 143 57 48
    78 116 92 39
  
50         
 82 89 123 50 55
    71 83 129 61
  
100         
 56 50 133 79 66
    71 48 114 53
  
200         
   
Positive Control Methyl Methane Sulfonate 
15         
 35 31 173 165 165*
    26 25 128 166

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 74 59 124 56 55
    62# 146 120 64
    60# 47 102 57
    57# 149 73.5 43
Test Chemical Pentachloroethane 
70         
 70# 113 174 83 121*
    42 46 199 158
  
90         
 46 18 190 137
  
110         
 32 13 168 173 126*
    55 78 130 79
  
130         
 63 66 176 94 125*
    41 15 194 157
  
150         
 19# 3 1444 2602 1397*
    55# 13 319 192
Positive Control Methyl Methane Sulfonate 
15         
 45# 73 334 246 219*
    30 17 170 191

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 101 99 210 69 72
    95 89 210 74
    70 104 168 80
    70 108 138 66
Test Chemical Pentachloroethane 
50         
 79 79 168 71 75
    78 80 183 78
  
70         
 83 69 222 89 95
    68 67 207 101
  
90         
 96 51 306 106 105
    113 51 352 104
  
110         
 79 20 426 181 197*
    87 23 555 213
  
130         
 57 6 1647 960 884*
    56 6 1353 808
  
150         
   
Positive Control Methyl Methane Sulfonate 
15         
 45 28 362 270 262*
    48 31 362 254

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination