Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02643-0001-0000-8 |
Chemical Name: | Pentachloronitrobenzene |
CASRN: | 82-68-8 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 027750_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Weakly Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1050 | 451 | 0.430 | 9.02 | 26.0 | 0.000 |
Test Chemical | Pentachloronitrobenzene | 0.5 | 50 | 1051 | 475 | 0.452 | 9.50 | 26.0 | 5.221 |
1.6 | 50 | 1050 | 552 | 0.526 | 11.04 | 26.0 | 22.395 | ||
5 | 50 | 1050 | 510 | 0.486 | 10.20 | 26.0 | 13.082 | ||
16 | 15 | 315 | 230 | 0.730 | 15.33 | 26.0 | 69.993 | ||
50 | 0 | 0 | 0 | 0.000 | 0.00 | 26.0 | N/A | ||
Positive Control | Mitomycin-C | 0.0E-4 | 50 | 1049 | 608 | 0.580 | 12.16 | 26.0 | 34.940 |
Mitomycin-C | 0.005 | 10 | 210 | 375 | 1.786 | 37.50 | 26.0 | 315.743 | |
Trend: | 5.360 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1048 | 463 | 0.442 | 9.26 | 26.0 | 0.000 |
Test Chemical | Pentachloronitrobenzene | 5 | 50 | 1041 | 497 | 0.477 | 9.94 | 26.0 | 8.065 |
10 | 50 | 1048 | 560 | 0.534 | 11.20 | 26.0 | 20.950 | ||
16 | 50 | 1049 | 678 | 0.646 | 13.56 | 26.0 | 46.297 | ||
25 | 50 | 1042 | 749 | 0.719 | 14.98 | 26.0 | 62.703 | ||
Positive Control | Mitomycin-C | 0.0E-4 | 50 | 1036 | 631 | 0.609 | 12.62 | 26.0 | 37.864 |
Mitomycin-C | 0.005 | 10 | 209 | 248 | 1.187 | 24.80 | 26.0 | 168.587 | |
Trend: | 9.716 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1050 | 435 | 0.414 | 8.70 | 26.0 | 0.000 |
Test Chemical | Pentachloronitrobenzene | 1.6 | 50 | 1051 | 443 | 0.422 | 8.86 | 26.0 | 1.742 |
5 | 50 | 1050 | 422 | 0.402 | 8.44 | 26.0 | -2.989 | ||
16 | 50 | 1050 | 467 | 0.445 | 9.34 | 26.0 | 7.356 | ||
50 | 50 | 1050 | 734 | 0.699 | 14.68 | 26.0 | 68.736 | ||
160 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.15 | 50 | 1049 | 622 | 0.593 | 12.44 | 26.0 | 43.125 |
Cyclophosphamide | 0.6 | 10 | 210 | 235 | 1.119 | 23.50 | 26.0 | 170.115 | |
Trend: | 8.797 | ||||||||
Probability: | 0.000 |