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Study Information
Study Attribute Value
CEBS Accession Number: 002-02643-0001-0000-8
Chemical Name: Pentachloronitrobenzene
CASRN: 82-68-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 027750_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 02/26/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 451 0.430 9.02 26.0 0.000
Test Chemical Pentachloronitrobenzene 
 0.5       
 50 1051 475 0.452 9.50 26.0 5.221 
1.6       
 50 1050 552 0.526 11.04 26.0 22.395 
5         
 50 1050 510 0.486 10.20 26.0 13.082 
16         
 15 315 230 0.730 15.33 26.0 69.993 
50         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 608 0.580 12.16 26.0 34.940
Mitomycin-C 
 0.005     
 10 210 375 1.786 37.50 26.0 315.743
Trend: 5.360        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/11/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 463 0.442 9.26 26.0 0.000
Test Chemical Pentachloronitrobenzene 
5         
 50 1041 497 0.477 9.94 26.0 8.065 
10         
 50 1048 560 0.534 11.20 26.0 20.950 
16         
 50 1049 678 0.646 13.56 26.0 46.297 
25         
 50 1042 749 0.719 14.98 26.0 62.703
Positive Control Mitomycin-C 
 0.0E-4    
 50 1036 631 0.609 12.62 26.0 37.864
Mitomycin-C 
 0.005     
 10 209 248 1.187 24.80 26.0 168.587
Trend: 9.716        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/01/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 435 0.414 8.70 26.0 0.000
Test Chemical Pentachloronitrobenzene 
1.6       
 50 1051 443 0.422 8.86 26.0 1.742 
5         
 50 1050 422 0.402 8.44 26.0 -2.989 
16         
 50 1050 467 0.445 9.34 26.0 7.356 
50         
 50 1050 734 0.699 14.68 26.0 68.736 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.15      
 50 1049 622 0.593 12.44 26.0 43.125
Cyclophosphamide 
 0.6       
 10 210 235 1.119 23.50 26.0 170.115
Trend: 8.797        
Probability: 0.000