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Study Information
Study Attribute Value
CEBS Accession Number: 002-02643-0002-0000-9
Chemical Name: Pentachloronitrobenzene
CASRN: 82-68-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 027750_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 04/02/1986    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 1.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: Pentachloronitrobenzene 
16         
 200 11 0.055 5.0 1 0.005 1.0 10 0.050 4.0 0 0.000 0.0 
30         
 200 10 0.050 5.0 1 0.005 1.0 9 0.045 5.0 0 0.000 0.0 
50         
 200 42 0.210 15.0 0 0.000 0.0 42 0.210 15.0 0 0.000 0.0 
100         
 200 28 0.140 10.0 0 0.000 0.0 28 0.140 10.0 0 0.000 0.0 
160         
 200 12 0.060 5.0 0 0.000 0.0 12 0.060 5.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 44 0.220 19.0 18 0.090 8.0 26 0.130 12.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 35 0.700 44.0 9 0.180 18.0 16 0.320 28.0 10 0.200 1.0
Trend: 3.007 -2.145 3.248  
Probability: 0.001 0.984 0.001  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/02/1986    Harvest Time: 13 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: Pentachloronitrobenzene 
50         
 200 7 0.035 4.0 0 0.000 0.0 7 0.035 4.0 0 0.000 0.0 
100         
 200 24 0.120 11.0 3 0.015 2.0 21 0.105 10.0 0 0.000 0.0 
160         
 200 11 0.055 6.0 2 0.010 1.0 9 0.045 5.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 24 0.120 12.0 7 0.035 4.0 17 0.085 9.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 14 0.280 24.0 9 0.180 16.0 5 0.100 8.0 0 0.000 0.0
Trend: 2.794 1.966 2.335  
Probability: 0.003 0.025 0.010  


Trial #:2   Activation: No Activation    Date: 04/16/1986    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 1.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: Pentachloronitrobenzene 
30         
 200 15 0.075 5.0 2 0.010 1.0 13 0.065 5.0 0 0.000 0.0 
50         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
100         
 200 9 0.045 4.0 0 0.000 0.0 9 0.045 4.0 0 0.000 0.0 
160         
 200 11 0.055 5.0 0 0.000 0.0 11 0.055 5.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 66 0.330 23.0 32 0.160 13.0 24 0.120 12.0 10 0.050 1.0
Mitomycin-C 
 0.25      
 50 21 0.420 34.0 11 0.220 22.0 10 0.200 16.0 0 0.000 0.0
Trend: 1.750 -2.110 1.750  
Probability: 0.040 0.983 0.040