Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-02643-0003-0000-0
Chemical Name: Pentachloronitrobenzene
CASRN: 82-68-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 114657_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/16/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 420 0.400 8.40 26.0 0.000
Test Chemical Pentachloronitrobenzene 
 0.75      
 50 1047 425 0.406 8.50 26.0 1.384 
2.4       
 50 1050 465 0.443 9.30 26.0 10.609 
7.5       
 50 1052 465 0.442 9.30 26.0 10.399
Positive Control Mitomycin-C 
 0.005     
 50 1049 836 0.797 16.72 26.0 99.048
Trend: 1.806        
Probability: 0.035        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/16/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 499 0.475 9.98 26.0 0.000
Test Chemical Pentachloronitrobenzene 
7.5       
 50 1045 436 0.417 8.72 26.0 -12.124 
24         
 50 1047 551 0.526 11.02 26.0 10.843 
75         
 50 1044 466 0.446 9.32 26.0 -5.987
Positive Control Cyclophosphamide 
1         
 25 523 458 0.876 18.32 26.0 84.445
Trend: 0.264        
Probability: 0.396