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Study Information
Study Attribute Value
CEBS Accession Number: 002-02643-0004-0000-1
Chemical Name: Pentachloronitrobenzene
CASRN: 82-68-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 114657_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Questionable 

Trial #:1   Activation: No Activation    Date: 02/16/1983    Harvest Time: 14 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Pentachloronitrobenzene 
2.4       
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0 
7.5       
 100 28 0.280 16.0 2 0.020 2.0 25 0.250 15.0 1 0.010 0.0 
24         
 100 22 0.220 19.0 1 0.010 1.0 20 0.200 18.0 1 0.010 0.0 
75         
 100 17 0.170 10.0 2 0.020 2.0 15 0.150 9.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 22 0.440 24.0 5 0.100 10.0 17 0.340 20.0 0 0.000 0.0
Trend: 2.876 0.869 2.872  
Probability: 0.002 0.193 0.002  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/16/1983    Harvest Time: 14 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Pentachloronitrobenzene 
2.4       
 100 8 0.080 8.0 1 0.010 1.0 7 0.070 7.0 0 0.000 0.0 
7.5       
 100 10 0.100 9.0 6 0.060 6.0 4 0.040 4.0 0 0.000 0.0 
24         
 100 6 0.060 6.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0 
75         
 32 6 0.188 13.0 2 0.063 3.0 4 0.125 13.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 11 0.220 18.0 6 0.120 10.0 5 0.100 10.0 0 0.000 0.0
Trend: 1.467 1.054 1.411  
Probability: 0.071 0.146 0.079