| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02643-0012-0000-0 |
| Chemical Name: | Pentachloronitrobenzene |
| CASRN: | 82-68-8 |
| NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
| NTP Study ID: | 303135 |
| Study Result: | Negative |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Acetone | 0 | 114 | 102 | 115 | 34 | 32 |
| 71 | 95 | 60 | 28 | ||||
| 99# | 95 | 101 | 34 | ||||
| 88 | 109 | 86 | 33 | ||||
| Test Chemical | Pentachloronitrobenzene | 1.25 | 94 | 107 | 65 | 23 | 34 |
| 84# | 93 | 84 | 33 | ||||
| 71# | 73 | 98 | 46 | ||||
2.5 | 105 | 89 | 67 | 21 | 25 | ||
| 113 | 84 | 80 | 24 | ||||
| 100 | 81 | 92 | 31 | ||||
5 | 102 | 83 | 142 | 46 | 31 | ||
| 80 | 83 | 53 | 22 | ||||
| 114 | 100 | 83 | 24 | ||||
10 | 125r | 66 | 127 | 34 | 44 | ||
| 89 | 63 | 100 | 37 | ||||
| 80# | 67 | 121 | 50 | ||||
20 | 144r | 58 | 154 | 36 | 37 | ||
| 109 | 58 | 120 | 37 | ||||
| 108 | 55 | 124 | 38 | ||||
30 | 100 | 37 | 99 | 33 | 41 | ||
| 96# | 32 | 146 | 51 | ||||
| 87 | 51 | 103 | 40 | ||||
| Positive Control | Methyl Methane Sulfonate | 5 | 71 | 34 | 616 | 289 | 279* |
| 84 | 67 | 637 | 254 | ||||
| 72 | 43 | 632 | 294 | ||||
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Acetone | 0 | 117 | 102 | 92 | 26 | 31 |
| 133r | 116 | 99 | 25 | ||||
| 112 | 111 | 107 | 32 | ||||
| 100 | 88 | 102 | 34 | ||||
| Test Chemical | Pentachloronitrobenzene | 1.25 | 95 | 88 | 96 | 34 | 30 |
| 86 | 82 | 74 | 29 | ||||
| 94 | 71 | 80 | 28 | ||||
2.5 | 93 | 84 | 86 | 31 | 28 | ||
| 103 | 89 | 70 | 23 | ||||
| 89 | 87 | 83 | 31 | ||||
5 | 85 | 66 | 88 | 34 | 34 | ||
| 115 | 80 | 116 | 34 | ||||
| 106 | 81 | 108 | 34 | ||||
7.5 | 108 | 99 | 63 | 20 | 24 | ||
| 115 | 101 | 88 | 25 | ||||
| 97 | 89 | 75 | 26 | ||||
10 | 112 | 99 | 63 | 19 | 24 | ||
| 111 | 71 | 85 | 26 | ||||
| 81 | 79 | 69 | 28 | ||||
15 | 122r | 69 | 111 | 30 | 32 | ||
| 81 | 65 | 88 | 36 | ||||
| 95 | 77 | 79 | 28 | ||||
| Positive Control | Methyl Methane Sulfonate | 5 | 89 | 52 | 439 | 164 | 208* |
| 57 | 37 | 391 | 230 | ||||
| 72 | 42 | 494 | 229 | ||||
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Acetone | 0 | 113 | 117 | 50 | 15 | 23 |
| 91# | 84 | 75 | 28 | ||||
| 91 | 102 | 60 | 22 | ||||
| 113 | 97 | 87 | 26 | ||||
| Test Chemical | Pentachloronitrobenzene | 1.25 | 97 | 81 | 80 | 28 | 30 |
| 95 | 64 | 60 | 21 | ||||
| 86 | 65 | 108 | 42 | ||||
2.5 | 113 | 89 | 88 | 26 | 25 | ||
| 94 | 81 | 43 | 15 | ||||
| 91 | 79 | 90 | 33 | ||||
5 | 104 | 71 | 112 | 36 | 24 | ||
| 83 | 81 | 46 | 18 | ||||
| 103 | 83 | 57 | 19 | ||||
7.5 | 94 | 79 | 68 | 24 | 29 | ||
| 100 | 72 | 79 | 26 | ||||
| 89 | 76 | 97 | 36 | ||||
10 | 91 | 59 | 42 | 15 | 17 | ||
| 102 | 85 | 48 | 16 | ||||
| 111 | 78 | 69 | 21 | ||||
15 | 102# | 61 | 131 | 43 | 32 | ||
| 121r | 73 | 128 | 35 | ||||
| 117 | 66 | 74 | 21 | ||||
| Positive Control | 3-Methylcholanthrene | 2.5 | 52 | 28 | 599 | 380 | 415* |
| 66 | 33 | 761 | 383 | ||||
| 45 | 28 | 648 | 480 | ||||
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Acetone | 0 | 83 | 104 | 59 | 24 | 27 |
| 102 | 116 | 74 | 24 | ||||
| 75 | 93 | 77 | 34 | ||||
| 86 | 87 | 70 | 27 | ||||
| Test Chemical | Pentachloronitrobenzene | 1.25 | 82 | 81 | 74 | 30 | 28 |
| 86 | 79 | 68 | 26 | ||||
| 82 | 89 | 71 | 29 | ||||
2.5 | 101 | 90 | 107 | 35 | 33 | ||
| 79 | 79 | 72 | 30 | ||||
| 81 | 89 | 80 | 33 | ||||
5 | 86# | 79 | 78 | 30 | 28 | ||
| 109 | 98 | 85 | 26 | ||||
| 86 | 91 | 71 | 27 | ||||
7.5 | 109 | 85 | 97 | 30 | 30 | ||
| 98 | 89 | 89 | 30 | ||||
| 101 | 102 | 87 | 29 | ||||
10 | 88 | 92 | 80 | 30 | 31 | ||
| 99 | 80 | 84 | 28 | ||||
| 90 | 83 | 92 | 34 | ||||
15 | 107 | 79 | 80 | 25 | 26 | ||
| 97 | 86 | 71 | 24 | ||||
| 82# | 69 | 72 | 29 | ||||
| Positive Control | 3-Methylcholanthrene | 2.5 | 78 | 38 | 778 | 331 | 402* |
| 58 | 46 | 625 | 360 | ||||
| 50 | 33 | 775 | 515 | ||||
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination