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Study Information
Study Attribute Value
CEBS Accession Number: 002-02644-0001-0000-9
Chemical Name: Pentachlorophenol, technical
CASRN: 87-86-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 646893_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/07/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 413 0.393 8.26 26.0 0.000
Test Chemical Pentachlorophenol, technical 
1         
 50 1048 410 0.391 8.20 26.0 -0.537 
3         
 50 1047 498 0.476 9.96 26.0 20.927 
10         
 50 1041 449 0.431 8.98 26.0 9.657 
30         
 45 939 425 0.453 9.44 28.0 15.070
Positive Control Triethylenemelamine 
 0.015     
 50 1051 1506 1.433 30.12 26.0 264.302
Trend: 2.427        
Probability: 0.008        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/07/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 474 0.452 9.48 26.0 0.000
Test Chemical Pentachlorophenol, technical 
3         
 50 1047 555 0.530 11.10 26.0 17.312 
10         
 50 1050 523 0.498 10.46 26.0 10.232 
30         
 50 1050 529 0.504 10.58 26.0 11.497 
100         
 50 1050 548 0.522 10.96 28.0 15.502
Positive Control Cyclophosphamide 
1         
 50 1049 1114 1.062 22.28 26.0 135.021
Trend: 1.650        
Probability: 0.049