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Study Information
Study Attribute Value
CEBS Accession Number: 002-02644-0002-0000-0
Chemical Name: Pentachlorophenol, technical
CASRN: 87-86-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 646893_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 
Induced Rat Liver S9  2_S9  Questionable 

Trial #:1   Activation: No Activation    Date: 10/07/1981    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Pentachlorophenol, technical 
10         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
30         
 100 5 0.050 4.0 2 0.020 1.0 3 0.030 3.0 0 0.000 0.0 
100         
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.015     
 100 25 0.250 22.0 9 0.090 9.0 16 0.160 14.0 0 0.000 0.0
Trend: 1.217 0.419 1.143  
Probability: 0.112 0.338 0.127  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/07/1981    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Pentachlorophenol, technical 
3         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
10         
 100 9 0.090 7.0 1 0.010 1.0 8 0.080 7.0 0 0.000 0.0 
30         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
100         
 100 65 0.650 33.0 12 0.120 9.0 53 0.530 27.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 33 0.330 26.0 15 0.150 14.0 18 0.180 14.0 0 0.000 0.0
Trend: 6.188 3.730 5.329  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 12/09/1981    Harvest Time: 14 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 0 0.000 0.0 4 0.040 3.0 0 0.000 0.0
Test Chemical: Pentachlorophenol, technical 
10         
 100 9 0.090 9.0 1 0.010 1.0 8 0.080 8.0 0 0.000 0.0 
60         
 100 14 0.140 10.0 3 0.030 3.0 11 0.110 9.0 0 0.000 0.0 
70         
 100 10 0.100 10.0 1 0.010 1.0 9 0.090 9.0 0 0.000 0.0 
80         
 100 15 0.150 12.0 5 0.050 3.0 10 0.100 9.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 33 0.330 27.0 13 0.130 11.0 20 0.200 17.0 0 0.000 0.0
Trend: 2.091 1.669 1.671  
Probability: 0.018 0.048 0.047